Article

Inverse directions of association of higher physical activity and higher insulin resistance with human skeletal muscle cell typae abundance and fiber-type-level gene expression

2025-10-28

Abstract excerpt

<h4>Summary</h4> To investigate the interplay between physical activity and cardiometabolic traits in human skeletal muscle, we characterized gene expression and chromatin accessibility across skeletal muscle cell types in 263 Finnish individuals from the FUSION Tissue Biopsy Study. We analyzed skeletal muscle single-nucleus RNA-seq data (168,309 nuclei, 23,849 genes), ATAC-seq data (242,069 nuclei, 927,588 peaks...

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Literature Corpus work: 4936ee8a-dc35-5cd7-a328-195fb670694e
DOI: 10.1101/2025.10.27.683567

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