Article

Cell type–resolved transcriptomic map of skeletal muscle in women with polycystic ovary syndrome

2026-06-01

Abstract excerpt

<title>Abstract</title> <p>Polycystic ovary syndrome (PCOS) is associated with skeletal muscle insulin resistance, fibrosis, and lipotoxicity, yet the cellular origins remain unknown. Here, we present a comprehensive cellular atlas of skeletal muscle from hyperinsulinemic and hyperandrogenic women with PCOS and controls of similar age, weight, and BMI. Analysis of 72,247 nuclei from 19 biopsies revealed cell-type...

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Literature Corpus work: 297a9dc5-354a-5ba9-bf2d-c82647606b5a
DOI: 10.21203/rs.3.rs-9245852/v1

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