The genetic regulatory signature of type 2 diabetes in human skeletal muscle.

doi:10.1038/ncomms11764

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Article

The genetic regulatory signature of type 2 diabetes in human skeletal muscle.

Nature communications - 29 Jun 2016

Scott Laura J, Erdos Michael R, Huyghe Jeroen R, Welch Ryan P, Beck Andrew T, Wolford Brooke N, Chines Peter S, Didion John P, Narisu Narisu, Stringham Heather M, Taylor D Leland, Jackson Anne U, Vadlamudi Swarooparani, Bonnycastle Lori L, Kinnunen Leena, Saramies Jouko, Sundvall Jouko, Albanus Ricardo D'Oliveira, Kiseleva Anna, Hensley John, Crawford Gregory E, Jiang Hui, Wen Xiaoquan, Watanabe Richard M, Lakka Timo A, Mohlke Karen L, Laakso Markku, Tuomilehto Jaakko, Koistinen Heikki A, Boehnke Michael, Collins Francis S, Parker Stephen C J

Abstract excerpt

Type 2 diabetes (T2D) results from the combined effects of genetic and environmental factors on multiple tissues over time. Of the >100 variants associated with T2D and related traits in genome-wide association studies (GWAS), >90% occur in non-coding regions, suggesting a strong regulatory component to T2D risk. Here to understand how T2D status, metabolic traits and genetic variation influence gene expression,...

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PMID: 27353450
DOI: 10.1038/ncomms11764
PMCID: PMC4931250

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