Article

A full-length single nuclei transcriptomic atlas of human skeletal muscle insulin resistance

2026-02-28

Abstract excerpt

<h4>Summary</h4> Skeletal muscle (SkM) insulin resistance is a central defect in T2D, yet cell specific molecular determinants remain incompletely understood. Here, we integrate full-length single-nucleus transcriptomics with gold-standard stable isotope-labeled hyperinsulinemic-euglycemic clamps to generate a nucleus-resolved transcriptomic atlas of SkM insulin resistance. We identify previously unrecognized myo...

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Literature Corpus work: 661bc2ff-781f-5840-8a6c-717ef419dd5c
DOI: 10.64898/2026.02.26.708250

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