Article

Cell type–resolved transcriptomic map of skeletal muscle in women with polycystic ovary syndrome

2026-03-17

Abstract excerpt

<h4>Summary</h4> Polycystic ovary syndrome (PCOS) is associated with skeletal muscle insulin resistance, fibrosis, and lipotoxicity, yet the cellular origins remain unknown. Here, we present a comprehensive cellular atlas of skeletal muscle from hyperinsulinemic and hyperandrogenic women with PCOS and controls of similar age, weight, and BMI. Analysis of 72,247 nuclei from 19 biopsies revealed cell-type-specific...

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Literature Corpus work: 85a11620-88cf-5577-9f14-181b27745e39
DOI: 10.64898/2026.03.13.711523

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