Article

LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility

2023-02-26

Abstract excerpt

Radial spokes (RS) are T-shaped multiprotein complexes on the axonemal microtubules. Repeated RS1, RS2, and RS3 couple the central pair to modulate ciliary and flagellar motility. Despite the cell type specificity of RS3 substructures, their molecular components remain largely unknown. Here, we report that a leucine-rich repeat-containing protein, LRRC23, is an RS3 head component essential for its head assembly an...

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Identifiers and source

Literature Corpus work: 49323127-06e0-5261-b369-2e77b753466a
DOI: 10.1101/2023.02.25.530050

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