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Article

LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice

29 Sept 2021

Abstract excerpt

Cilia and flagella are ancient structures that achieve controlled motor functions through the coordinated interaction based on microtubules and some attached projections. Radial spokes (RSs) facilitate the beating motion of these organelles by mediating signal transduction between dyneins and a central pair (CP) of singlet microtubules. RS complex isolation from Chlamydomonas axonemes enabled the detection of 23...

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PMID: 34585727
DOI: 10.1242/jcs.259381

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Related research

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LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in micePMID 34585727Read ↗

LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertilitySemantic proximity Read ↗

RSPH6A is required for sperm flagellum formation and male fertility in mice.Semantic proximity Read ↗

LRRC23 deficiency causes male infertility with idiopathic asthenozoospermia by disrupting the assembly of radial spokesSemantic proximity Read ↗

Rsph4a is essential for the triplet radial spoke head assembly of the mouse motile cilia.Semantic proximity Read ↗

Heterogeneity of radial spokes structural components and associated enzymes in <i>Tetrahymena</i> ciliaSemantic proximity Read ↗

RSPH3 Mutations Cause Primary Ciliary Dyskinesia with Central-Complex Defects and a Near Absence of Radial Spokes.Semantic proximity Read ↗

Rsph9 is critical for ciliary radial spoke assembly and central pair microtubule stabilitySemantic proximity Read ↗

Loss-of-function mutations in RSPH1 cause primary ciliary dyskinesia with central-complex and radial-spoke defects.Semantic proximity Read ↗

DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in miceSemantic proximity Read ↗

FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and piRNA productionSemantic proximity Read ↗

TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa.Semantic proximity Read ↗

Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalities.Semantic proximity Read ↗

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