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Article

Structural insights into the cause of human RSPH4A primary ciliary dyskinesia.

Molecular biology of the cell - 1 Jun 2021

Zhao Yanhe, Pinskey Justine, Lin Jianfeng, Yin Weining, Sears Patrick R, Daniels Leigh A, Zariwala Maimoona A, Knowles Michael R, Ostrowski Lawrence E, Nicastro Daniela

Abstract excerpt

Cilia and flagella are evolutionarily conserved eukaryotic organelles involved in cell motility and signaling. In humans, mutations in Radial Spoke Head Component 4A (RSPH4A) can lead to primary ciliary dyskinesia (PCD), a life-shortening disease characterized by chronic respiratory tract infections, abnormal organ positioning, and infertility. Despite its importance for human health, the location of RSPH4A in...

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Identifiers

PMID: 33852348
DOI: 10.1091/mbc.E20-12-0806
PMCID: PMC8351563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural insights into the cause of human RSPH4A primary ciliary dyskinesia.PMID 33852348Read ↗

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