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In situ structure of the mouse sperm central apparatus reveals mechanistic insights into asthenozoospermia

4 Jun 2025

Abstract excerpt

The central apparatus (CA) within the sperm axoneme is vital for sperm motility, yet its molecular architecture and functional mechanisms remain incompletely understood. Combining cryo-electron tomography and AlphaFold2, we resolved the in-cell structure of mouse sperm CA at a subnanometer resolution and built a near-complete atomic model. Our analysis identified 39 CA-associated proteins, including eight...

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PMID: 40473901
DOI: 10.1038/s41422-025-01135-2

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