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Article

Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jan 2021

Zheng Wei, Li Fan, Ding Zhanyu, Liu Hao, Zhu Lei, Xu Cong, Li Jiawei, Gao Qi, Wang Yanxing, Fu Zhenglin, Peng Chao, Yan Xiumin, Zhu Xueliang, Cong Yao

Abstract excerpt

The radial spoke (RS) heads of motile cilia and flagella contact projections of the central pair (CP) apparatus to coordinate motility, but the morphology is distinct for protozoa and metazoa. Here we show the murine RS head is compositionally distinct from that of Chlamydomonas Our reconstituted murine RS head core complex consists of Rsph1, Rsph3b, Rsph4a, and Rsph9, lacking Rsph6a and Rsph10b, whose orthologs...

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Identifiers

PMID: 34871179
DOI: 10.1073/pnas.2021180118
PMCID: PMC7848523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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