Article

FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and piRNA production

2023-10-01

Abstract excerpt

Spermiogenesis is a critical, post-meiotic phase of male gametogenesis, in which the proper gene expression is essential for sperm maturation. However, the underlying molecular mechanism that controls mRNA expression in the round spermatids remains elusive. Here, we identify that FBXO24, an orphan F-box protein, is highly expressed in the testis of humans and mice and interacts with the splicing factors (SRSF2, SR...

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Literature Corpus work: f3e4e592-ba0d-5982-a7a6-2a33b379d681
DOI: 10.1101/2023.10.01.560355

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