Article
Novel mutations in LRRC23 cause asthenozoospermia in a nonconsanguineous family.
Asian journal of andrology - 1 Sept 2024
Tang Song-Xi, Liu Si-Yu, Xiao Hong, Zhang Xin, Xiao Zhuang, Zhou Shan, Ding Yi-Lang, Yang Peng, Chen Qiang, Huang Hai-Lin, Chen Xi, Lin Xi, Zhou Hui-Liang, Liu Ming-Xi
Abstract excerpt
ABSTRACT: The cause of asthenozoospermia (AZS) is not well understood because of its complexity and heterogeneity. Although some gene mutations have been identified as contributing factors, they are only responsible for a small number of cases. Radial spokes (RSs) are critical for adenosine triphosphate-driven flagellar beating and axoneme stability, which is essential for flagellum motility. In this study, we...
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