Article

Surface proteins of SARS-CoV-2 drive airway epithelial cells to induce interferon-dependent inflammation

2020-12-14

Abstract excerpt

SARS-CoV-2, the virus that has caused the COVID-19 pandemic, robustly activates the host immune system in critically ill patients. Understanding how the virus engages the immune system will facilitate the development of needed therapeutic strategies. Here we demonstrate both in vitro and in vivo that the SARS-CoV-2 surface proteins Spike (S) and Envelope (E) activate the key immune signaling interferon (IFN) pathw...

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Identifiers and source

Literature Corpus work: 49223e81-a763-5505-874e-e3e8da362b5f
DOI: 10.1101/2020.12.14.422710

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