Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

1 Jan 2021

Abstract excerpt

Recent studies have profiled the innate immune signatures in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and suggest that cellular responses to viral challenge may affect disease severity. Yet the molecular events that underlie cellular recognition and response to SARS-CoV-2 infection remain to be elucidated. Here, we find that SARS-CoV-2 replication induces a delayed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to interferon and immune responses
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33440148
DOI: 10.1016/j.celrep.2020.108628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial CellsPMID 33440148Read ↗

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial CellsSemantic proximity Read ↗

The RNA sensor MDA5 detects SARS-CoV-2 infectionSemantic proximity Read ↗

SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial CellsSemantic proximity Read ↗

SARS-CoV-2 replication triggers an MDA-5-dependent interferon production which is unable to efficiently control replicationSemantic proximity Read ↗

Mechanisms of impairment of interferon production by SARS-CoV-2Semantic proximity Read ↗

Surface proteins of SARS-CoV-2 drive airway epithelial cells to induce interferon-dependent inflammationSemantic proximity Read ↗

Differential roles of RIG-I-like receptors in SARS-CoV-2 infectionSemantic proximity Read ↗

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial CulturesSemantic proximity Read ↗

Comparative transcriptome analysis reveals the intensive early-stage responses of host cells to SARS-CoV-2 infectionSemantic proximity Read ↗

Role of interferons in the antiviral battle: from virus-host crosstalk to prophylactic and therapeutic potential in SARS-CoV-2 infectionSemantic proximity Read ↗

Suppression of MDA5-mediated antiviral immune responses by NSP8 of SARS-CoV-2Semantic proximity Read ↗

Manipulation of innate immune signaling pathways by SARS-CoV-2 non-structural proteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.