Article

SARS-CoV-2 Envelope protein (E) binds and activates TLR2: A novel target for COVID-19 interventions

2021-11-12

Abstract excerpt

In this study, we present a molecular characterization of the interaction between the SARS-CoV-2 envelope protein E with TLR2. We demonstrated that E protein interacts physically with TLR2 receptor in a specific and dose-dependent manner. Furthermore, we showed that this interaction is able to engage TLR2 pathway as demonstrated by its capacity to activate NF-κB transcription factor and to stimulate the production...

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Literature Corpus work: ee89a251-fcc2-548e-804f-eb379d617210
DOI: 10.1101/2021.11.10.468173

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