Article

Defective type I interferon immunity is associated with increasing COVID-19 severity

2022-06-16

Abstract excerpt

<title>Abstract</title> <p>Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical outcomes ranging from asymptomatic to severe disease and death. We previously reported that reduced blood type I interferon (IFN-I) in severe COVID-19 patients preceded clinical worsening. These results were supported by studies which identified genetic mutations in loci of the TLR3- or TLR7-depend...

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Literature Corpus work: dd307282-7710-5d88-be25-695a5c1ff834
DOI: 10.21203/rs.3.rs-1685544/v1

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