Article

Directed disruption of IL2 aggregation sites produces designer biologics with enhanced specificity coupled to improved production capacity

2024-09-03

Abstract excerpt

The pleotropic nature of interleukin-2 (IL2) has allowed it to be used as both a pro-inflammatory and anti-inflammatory therapeutic agent, through promotion of regulatory T cell (Treg) responses via the IL2RA receptor or promotion of CD8 T cell responses via the IL2RB receptor, respectively. However, the utility of IL2 as a treatment is limited by this same pleiotropy, and protein engineering to bias specificity t...

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Literature Corpus work: 1d03378a-28d7-55ad-8f0b-f07e6b7e90cc
DOI: 10.1101/2024.09.02.610760

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