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Article

Insights into the binding recognition and computational design of IL-2 muteins with enhanced predicted binding affinity to the IL-2 receptor α.

Journal of molecular graphics & modelling - 1 Dec 2024

Charoenwongpaiboon Thanapon, Klaewkla Methus

Abstract excerpt

Interleukin-2 (IL-2) is an immune system regulator that has received approval for cancer treatment. However, high-dose IL-2 therapy has seen restricted use due to its low efficacy and on-target toxicity. To enhance the effectiveness of IL-2 therapy, it is essential to engineer IL-2 molecules to enhance their specificity toward target cell populations. In this study, molecular dynamics (MD) simulations and Rosetta...

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PMID: 39405983
DOI: 10.1016/j.jmgm.2024.108883

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