Article

Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome

2024-04-03

Abstract excerpt

<title>Abstract</title> <p>DNA methylation at cytosine bases of eukaryotic DNA (5-methylcytosine, 5mC) is a heritable epigenetic mark that can regulate gene expression in health and disease. Enzymes that metabolize 5mC have been well-characterized, yet the discovery of endogenously produced signaling molecules that regulate DNA methyl-modifying machinery have not been described. Herein, we report that the free ra...

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Literature Corpus work: 48fd9de3-8232-5b56-9d34-8711449540e7
DOI: 10.21203/rs.3.rs-4131804/v1

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