Article

Considering the <i>APOE</i> locus in polygenic scores for Alzheimer’s disease

2019-12-14

Abstract excerpt

Polygenic scores are a strategy to aggregate the small, additive effects of single nucleotide polymorphisms across the genome. With phenotypes like Alzheimer’s disease, which have a strong and well established genomic locus ( APOE) , the cumulative effect of genetic variants outside of this area has not been well established in a population-representative sample. Here we examine the association between polygenic s...

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Literature Corpus work: 48fd7cdb-14e7-5077-ac63-2a6c24485328
DOI: 10.1101/2019.12.10.19014365

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