Article

TRIB1 modulates transcriptional programming in breast cancer cells to regulate cell proliferation

2023-07-07

Abstract excerpt

The pseudokinase Tribbles Homolog 1 ( TRIB1 ) is a known driver of tumorigenesis in acute myeloid leukemia and is encoded upstream of the oncogene MYC at the 8q24 locus. We observed that TRIB1/MYC co-amplification is associated with decreased relapse-free and overall survival in breast cancer patients, but the role of TRIB1 in this disease has not been well characterized. TRIB1 knockdown in multiple breast ca...

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Literature Corpus work: 48f99e75-d6e6-5f08-ad0d-3acd7261b60c
DOI: 10.1101/2023.07.06.547928

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