Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation

22 Feb 2011

Abstract excerpt

The tribbles family of genes encodes pseudokinase proteins that are highly conserved in evolution. Instead of direct phosphorylation of target proteins, tribbles act as adaptors in signaling pathways for important cellular processes. These include mitogen-activated protein kinase kinase (MAPKK), CCAAT/enhancer-binding protein (C/EBP), activating transcription factor 4 (ATF4) and C/EBP-homologous protein (CHOP)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
Share to Genetic and Kidney Cyst Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21338441
DOI: 10.1111/j.1349-7006.2011.01914.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformationPMID 21338441Read ↗

Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisionsSemantic proximity Read ↗

Tribbles pseudokinases in cardiovascular diseases: Molecular mechanisms, genetic insights, and therapeutic prospects.Semantic proximity Read ↗

Differential ability of Tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemiaSemantic proximity Read ↗

Diverse functions of Tribbles homolog 3 in cancers and its potential as a therapeutic targetSemantic proximity Read ↗

Tribbles: A family of kinase-like proteins with potent signalling regulatory functionSemantic proximity Read ↗

TRIB1 modulates transcriptional programming in breast cancer cells to regulate cell proliferationSemantic proximity Read ↗

TRIB2 regulates normal and stress-induced thymocyte proliferationSemantic proximity Read ↗

Comprehensive pan-cancer analysis unveils the significant prognostic value and potential role in immune microenvironment modulation of TRIB3Semantic proximity Read ↗

Tribbles-1 Expression and Its Function to Control Inflammatory Cytokines, Including Interleukin-8 Levels are Regulated by miRNAs in Macrophages and Prostate Cancer Cells.Semantic proximity Read ↗

Impaired Phosphorylation and Ubiquitination by p70 S6 Kinase (p70S6K) and Smad Ubiquitination Regulatory Factor 1 (Smurf1) Promote Tribbles Homolog 2 (TRIB2) Stability and Carcinogenic Property in Liver CancerSemantic proximity Read ↗

Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathwaysSemantic proximity Read ↗

Tks adaptor proteins at a glanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.