Article

TRIB1 regulates tumour growth via controlling tumour-associated macrophage phenotypes and is associated with breast cancer survival and treatment response

2021-06-07

Abstract excerpt

<h4>Summary</h4> Molecular mechanisms that regulate tumour-associated macrophage (TAM) phenotype and function are incompletely understood. Here, we show that the pseudokinase TRIB1 is highly expressed by TAMs in breast cancer and that its expression correlates with response to chemotherapy and patient survival. We used immune-competent murine models of breast cancer to characterise the consequences of altered (re...

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Literature Corpus work: 8f5f16a0-cffd-5938-ad95-a68ac690848d
DOI: 10.1101/2021.06.07.446596

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