Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation

9 Dec 2020

Abstract excerpt

Abstract The transcription factor MYC is deregulated in almost all human cancers, especially in aggressive lymphomas, through chromosomal translocation, amplification, and transcription hyperactivation. Here, we report that high expression of tribbles homologue 3 (TRIB3) positively correlates with elevated MYC expression in lymphoma specimens; TRIB3 deletion attenuates the initiation and progression of MYC-driven...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33298911
DOI: 10.1038/s41467-020-20107-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradationPMID 33298911Read ↗

Comprehensive pan-cancer analysis unveils the significant prognostic value and potential role in immune microenvironment modulation of TRIB3Semantic proximity Read ↗

Diverse functions of Tribbles homolog 3 in cancers and its potential as a therapeutic targetSemantic proximity Read ↗

TRIB1 modulates transcriptional programming in breast cancer cells to regulate cell proliferationSemantic proximity Read ↗

TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcomaSemantic proximity Read ↗

Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformationSemantic proximity Read ↗

TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target.Semantic proximity Read ↗

Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisionsSemantic proximity Read ↗

TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcomaSemantic proximity Read ↗

TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcriptionSemantic proximity Read ↗

Advances in Thymosin β10 Research: Differential Expression, Molecular Mechanisms, and Clinical Implications in Cancer and Other ConditionsSemantic proximity Read ↗

TRIB1 regulates tumor growth via controlling tumor-associated macrophage phenotypes and is associated with breast cancer survival and treatment response.Semantic proximity Read ↗

Inducing TRIB2 Targeted Protein Degradation to Reverse Chemoresistance in Acute Myeloid LeukaemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.