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Article

Trib1 promotes acute myeloid leukemia progression by modulating the transcriptional programs of Hoxa9

31 Jul 2020

Abstract excerpt

The pseudokinase Trib1 functions as a myeloid oncogene that recruits the E3 ubiquitin ligase COP1 to C/EBPα and interacts with MEK1 to enhance extracellular signal-regulated kinase (ERK) phosphorylation. A close genetic effect of Trib1 on Hoxa9 has been observed in myeloid leukemogenesis, where Trib1 overexpression significantly accelerates Hoxa9-induced leukemia onset. However, the mechanism underlying how Trib1...

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PMID: 32730594
DOI: 10.1182/blood.2019004586

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