Article
Tribbles-1 Expression and Its Function to Control Inflammatory Cytokines, Including Interleukin-8 Levels are Regulated by miRNAs in Macrophages and Prostate Cancer Cells.
Frontiers in immunology - 1 Jan 2020
Niespolo Chiara, Johnston Jessica M, Deshmukh Sumeet R, Satam Swapna, Shologu Ziyanda, Villacanas Oscar, Sudbery Ian M, Wilson Heather L, Kiss-Toth Endre
Abstract excerpt
The pseudokinase TRIB1 controls cell function in a range of contexts, by regulating MAP kinase activation and mediating protein degradation via the COP1 ubiquitin ligase. TRIB1 regulates polarization of macrophages and dysregulated Trib1 expression in murine models has been shown to alter atherosclerosis burden and adipose homeostasis. Recently, TRIB1 has also been implicated in the pathogenesis of prostate...
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