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Article

BCL11A promotes myeloid leukemogenesis by repressing PU.1 target genes

29 Oct 2021

Abstract excerpt

The transcriptional repressor BCL11A is involved in hematological malignancies, B-cell development, and fetal-to-adult hemoglobin switching. However, the molecular mechanism by which it promotes the development of myeloid leukemia remains largely unknown. We find that Bcl11a cooperates with the pseudokinase Trib1 in the development of acute myeloid leukemia (AML). Bcl11a promotes the proliferation and engraftment...

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PMID: 34714913
DOI: 10.1182/bloodadvances.2021004558

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