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Article

TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription

16 Dec 2019

Abstract excerpt

The existence of breast cancer stem cells (BCSCs) is a major reason underlying cancer metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may ameliorate breast cancer relapse and therapy resistance. Here we report that expression of the pseudokinase Tribble 3 (TRIB3) positively associates with breast cancer stemness and progression. Elevated TRIB3 expression supports BCSCs by...

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PMID: 31844113
DOI: 10.1038/s41467-019-13700-6

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TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcriptionPMID 31844113Read ↗

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TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcomaSemantic proximity Read ↗

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