Article

Estrogen-related receptor genes underlie sex differences in cortical atrophy associated with isolated REM sleep behavior disorder

2025-04-16

Abstract excerpt

Isolated REM sleep behavior (iRBD) is a male predominant parasomnia characterized by abnormal dream-enacting movements in REM sleep. It is the prodromal manifestation most strongly associated with the development of synucleinopathies, such as Parkinson’s disease or dementia with Lewy bodies. While individuals with iRBD exhibit significant cortical atrophy shaped by distinct gene expression, sex-specific difference...

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Literature Corpus work: 40eaf14d-5e37-5c0f-9c97-ddf10da446f1
DOI: 10.1101/2025.04.14.25325684

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