Article
A genome-wide association analysis reveals new pathogenic pathways in gout.
Nature genetics - 1 Nov 2024
Major Tanya J, Takei Riku, Matsuo Hirotaka, Leask Megan P, Sumpter Nicholas A, Topless Ruth K, Shirai Yuya, Wang Wei, Cadzow Murray J, Phipps-Green Amanda J, Li Zhiqiang, Ji Aichang, Merriman Marilyn E, Morice Emily, Kelley Eric E, Wei Wen-Hua, McCormick Sally P A, Bixley Matthew J, Reynolds Richard J, Saag Kenneth G, Fadason Tayaza, Golovina Evgenia, O'Sullivan Justin M, Stamp Lisa K, Dalbeth Nicola, Abhishek Abhishek, Doherty Michael, Roddy Edward, Jacobsson Lennart T H, Kapetanovic Meliha C, Melander Olle, Andrés Mariano, Pérez-Ruiz Fernando, Torres Rosa J, Radstake Timothy, Jansen Timothy L, Janssen Matthijs, Joosten Leo A B, Liu Ruiqi, Gaal Orsolya I, Crişan Tania O, Rednic Simona, Kurreeman Fina, Huizinga Tom W J, Toes René, Lioté Frédéric, Richette Pascal, Bardin Thomas, Ea Hang Korng, Pascart Tristan, McCarthy Geraldine M, Helbert Laura, Stibůrková Blanka, Tausche Anne-K, Uhlig Till, Vitart Véronique, Boutin Thibaud S, Hayward Caroline, Riches Philip L, Ralston Stuart H, Campbell Archie, MacDonald Thomas M, Nakayama Akiyoshi, Takada Tappei, Nakatochi Masahiro, Shimizu Seiko, Kawamura Yusuke, Toyoda Yu, Nakaoka Hirofumi, Yamamoto Ken, Matsuo Keitaro, Shinomiya Nariyoshi, Ichida Kimiyoshi, Lee Chaeyoung, Bradbury Linda A, Brown Matthew A, Robinson Philip C, Buchanan Russell R C, Hill Catherine L, Lester Susan, Smith Malcolm D, Rischmueller Maureen, Choi Hyon K, Stahl Eli A, Miner Jeff N, Solomon Daniel H, Cui Jing, Giacomini Kathleen M, Brackman Deanna J, Jorgenson Eric M, Liu Hongbo, Susztak Katalin, Shringarpure Suyash, So Alexander, Okada Yukinori, Li Changgui, Shi Yongyong, Merriman Tony R
Abstract excerpt
Gout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide insights into the molecular mechanism of the poorly understood inflammatory component of gout from a genome-wide association study (GWAS) of 2.6 million people, including 120,295 people with prevalent gout. We detected 377 loci and 410 genetically...
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