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Article

Systemic Investigation of Promoter-wide Methylome and Genome Variations in Gout.

International journal of molecular sciences - 1 Jul 2020

Tseng Chia-Chun, Wong Man Chun, Liao Wei-Ting, Chen Chung-Jen, Lee Su-Chen, Yen Jeng-Hsien, Chang Shun-Jen

Abstract excerpt

Current knowledge of gout centers on hyperuricemia. Relatively little is known regarding the pathogenesis of gouty inflammation. To investigate the epigenetic background of gouty inflammation independent of hyperuricemia and its relationship to genetics, 69 gout patients and 1455 non-gout controls were included. Promoter-wide methylation was profiled with EPIC array. Whole-genome sequencing data were included for...

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PMID: 32630231
DOI: 10.3390/ijms21134702
PMCID: PMC7369819

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