Article

Novel Genetic Variants Associated with Gout Identified Through a Genome-Wide Study in the UK Biobank (N = 150,542)

2025-02-08

Abstract excerpt

Gout is a prevalent and painful form of inflammatory arthritis associated with hyperuricemia, which leads to monosodium urate crystal deposition in joints and surrounding tissues, triggering acute inflammatory responses. This disease is also closely linked to serious comorbidities, including cardiovascular diseases, chronic kidney diseases, diabetes, and increased mortality risk, significantly impacting global hea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 780025c4-70e7-5923-ae67-223bc37e8730
DOI: 10.1101/2025.02.07.25321834

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel Genetic Variants Associated with Gout Identified Through a Genome-Wide Study in the UK Biobank (N = 150,542)DOI 10.1101/2025.02.07.25321834Read

Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese.Semantic proximity Read

Genetic advances in gout: potential applications in clinical practiceSemantic proximity Read

The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies.Semantic proximity Read

Exploring metabolic changes in gout – Insights from a genetic studySemantic proximity Read

The Epidemiology and Genetics of Hyperuricemia and Gout across Major Racial Groups: A Literature Review and Population Genetics Secondary Database AnalysisSemantic proximity Read

The Genetic Immune Basis of Gout: Identification, Functional Characterization, and Therapeutic ImplicationsSemantic proximity Read

The Epidemiology and Genetics of Hyperuricemia and Gout Across Major Racial Groups: A literature Review and Population Genetics Secondary Data AnalysisSemantic proximity Read

Single-cell and genome-wide Mendelian randomization identifies causative genes for gout.Semantic proximity Read

The genetic basis of urate control and gout: Insights into molecular pathogenesis from follow-up study of genome-wide association study loci.Semantic proximity Read

Performance of gout definitions for genetic epidemiological studies: analysis of UK Biobank.Semantic proximity Read

A genome-wide association analysis of 2,622,830 individuals reveals new pathogenic pathways in goutSemantic proximity Read

Unraveling the genetic causes in large pedigrees with gout by whole‑exome sequencing.Semantic proximity Read