Article

The Genetic Immune Basis of Gout: Identification, Functional Characterization, and Therapeutic Implications

2025-09-17

Abstract excerpt

Gout, the most common inflammatory arthritis, is still managed mainly as a metabolic disorder, with treatment centered around urate lowering rather than blocking the immune response that drives gout flares. This emphasis reflects a historical view of gout as a disease of excess and diet, reinforced by genome-wide association studies (GWAS) that consistently detect urate transport and metabolism loci, while immune-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 088d9c85-32c6-5555-8095-2a8393742a17
DOI: 10.1101/2025.09.12.675974

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Genetic Immune Basis of Gout: Identification, Functional Characterization, and Therapeutic ImplicationsDOI 10.1101/2025.09.12.675974Read

A genome-wide association analysis reveals new pathogenic pathways in gout.Semantic proximity Read

The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies.Semantic proximity Read

Novel Genetic Variants Associated with Gout Identified Through a Genome-Wide Study in the UK Biobank (N = 150,542)Semantic proximity Read

A genome-wide association analysis of 2,622,830 individuals reveals new pathogenic pathways in goutSemantic proximity Read

Integrated multi-omics mapping of the causal landscape of gout across the circulating-tissue axis.Semantic proximity Read

Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to GoutSemantic proximity Read

Single-cell and genome-wide Mendelian randomization identifies causative genes for gout.Semantic proximity Read

The genetic basis of urate control and gout: Insights into molecular pathogenesis from follow-up study of genome-wide association study loci.Semantic proximity Read

Differential DNA Methylation of Networked Signaling, Transcriptional, Innate and Adaptive Immunity, and Osteoclastogenesis Genes and Pathways in GoutSemantic proximity Read

Genetic insights into therapeutic targets for gout: evidence from a multi-omics mendelian randomization study.Semantic proximity Read

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.Semantic proximity Read

Single-cell and genome-wide Mendelian randomization identifies causative genes for goutSemantic proximity Read