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Article

Integrated multi-omics mapping of the causal landscape of gout across the circulating-tissue axis.

Frontiers in immunology - 1 Jan 2026

Huang Liang, Liu Jiani, Zheng Xiaohui, Zhang Kai, Chen Yixin, Chen Xiaoling, Zhang Siqi, Cai Shanshan, Cai Li, Guo Yanyan, Zhu Peng, Li Meng

Abstract excerpt

Background: Gout is a prevalent inflammatory arthropathy driven by monosodium urate crystal deposition, yet the causal relationships between circulating biomarkers and disease susceptibility remain incompletely characterized. Establishing robust causal associations and mapping them to specific effector genes and tissues is essential for identifying mechanistically informed therapeutic targets. Methods: We...

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Identifiers

PMID: 41816332
DOI: 10.3389/fimmu.2026.1776456
PMCID: PMC12971693

Genes

CAD
ITIH3
LMAN2
NIPAL1
PRELID1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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