Article
Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers.
Nature communications - 11 May 2020
Di Tano Maira, Raucci Franca, Vernieri Claudio, Caffa Irene, Buono Roberta, Fanti Maura, Brandhorst Sebastian, Curigliano Giuseppe, Nencioni Alessio, de Braud Filippo, Longo Valter D
Abstract excerpt
Fasting-mimicking diets delay tumor progression and sensitize a wide range of tumors to chemotherapy, but their therapeutic potential in combination with non-cytotoxic compounds is poorly understood. Here we show that vitamin C anticancer activity is limited by the up-regulation of the stress-inducible protein heme-oxygenase-1. The fasting-mimicking diet selectivity reverses vitamin C-induced up-regulation of...
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