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Article

FTO promotes colorectal cancer progression and chemotherapy resistance via demethylating G6PD/PARP1

1 Mar 2022

Abstract excerpt

Cytotoxic chemotherapy has long been the backbone of treatment for colorectal cancer (CRC) in patients. In spite of advances in therapy, the 5-year survival rate is still unsatisfactory, mostly due to chemotherapy resistance in the therapy process.1, 2 In our study, we demonstrated that the fat mass and obesity-associated (FTO) protein promotes CRC progression and increases chemotherapy resistance, thus,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35297218
DOI: 10.1002/ctm2.772

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