Article

A machine learning and drug repurposing approach to target ferroptosis in colorectal cancer stratified by sex and KRAS

2024-06-28

Abstract excerpt

The landscape of sex differences in Colorectal Cancer (CRC) has not been well characterized with respect to the mechanisms of action for oncogenes such as KRAS. However, our recent study showed that tumors from male patients with KRAS mutations have decreased iron-dependent cell death called ferroptosis. Building on these findings, we further examined ferroptosis in CRC, considering both sex of the patient and KRA...

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Literature Corpus work: aa2faa85-c7bf-5420-aae3-7f9047f7bf70
DOI: 10.1101/2024.06.24.600340

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