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B7H3 increases ferroptosis resistance by inhibiting cholesterol metabolism in colorectal cancer

3 Sept 2023

Abstract excerpt

Ferroptosis, a newly discovered form of regulated cell death, has been reported to be associated with multiple cancers, including colorectal cancer (CRC). However, the underlying molecular mechanism is still unclear. In this study, we identified B7H3 as a potential regulator of ferroptosis resistance in CRC. B7H3 knockdown decreased but B7H3 overexpression increased the ferroptosis resistance of CRC cells, as...

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PMID: 37661645
DOI: 10.1111/cas.15944

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