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Type I Interferon Signature Strength Correlates with Alloimmunization-Associated Transcriptomic Programs in Systemic Lupus Erythematosus: A Multi-Cohort Analysis

2026-04-06

Abstract excerpt

Red blood cell (RBC) alloimmunization is a clinically significant complication in transfused patients whose immunological determinants remain incompletely understood. Type I interferon (IFN-I) signaling drives RBC alloimmunization in murine models, and systemic lupus erythematosus (SLE) is characterized by constitutive IFN-I hyperactivation alongside elevated alloimmunization rates. We analyzed three publicly avai...

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Literature Corpus work
283251b9-00a0-5bc2-8687-a10a46466303
DOI
10.64898/2026.04.04.26350150
Open publication

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Type I Interferon Signature Strength Correlates with Alloimmunization-Associated Transcriptomic Programs in Systemic Lupus Erythematosus: A Multi-Cohort AnalysisDOI 10.64898/2026.04.04.26350150
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