Article
Relative performance of gene- and pathway-level methods as secondary analyses for genome-wide association studies.
BMC genetics - 8 Apr 2015
Wojcik Genevieve L, Kao W H Linda, Duggal Priya
Abstract excerpt
BACKGROUND: Despite the success of genome-wide association studies (GWAS), there still remains "missing heritability" for many traits. One contributing factor may be the result of examining one marker at a time as opposed to a group of markers that are biologically meaningful in aggregate. To address this problem, a variety of gene- and pathway-level methods have been developed to identify putative biologically...
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