Article

Leveraging polygenic functional enrichment to improve GWAS power

2017-11-20

Abstract excerpt

Functional genomics data has the potential to increase GWAS power by identifying SNPs that have a higher prior probability of association. Here, we introduce a method that leverages polygenic functional enrichment to incorporate coding, conserved, regulatory and LD-related genomic annotations into association analyses. We show via simulations with real genotypes that the method, Functionally Informed Novel Discove...

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Literature Corpus work: c162e7bd-2dcd-528e-8c0d-4ea1b1245be0
DOI: 10.1101/222265

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