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Article

Gene and Network Analysis of Common Variants Reveals Novel Associations in Multiple Complex Diseases.

Genetics - 1 Oct 2016

Nakka Priyanka, Raphael Benjamin J, Ramachandran Sohini

Abstract excerpt

Genome-wide association (GWA) studies typically lack power to detect genotypes significantly associated with complex diseases, where different causal mutations of small effect may be present across cases. A common, tractable approach for identifying genomic elements associated with complex traits is to evaluate combinations of variants in known pathways or gene sets with shared biological function. Such gene-set...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27489002
DOI: 10.1534/genetics.116.188391
PMCID: PMC5068862

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