Article

APOE Genotype Differentially Modulates Prion Pathology in a Mouse Model

2025-10-30

Abstract excerpt

<title>Abstract</title> <p> <italic>APOE</italic> polymorphism affects the risk of occurrence and the rate of progression in several neurodegenerative diseases including Alzheimer’s disease, primary tauopathies, α-synucleinopathy, and age-related macular degeneration, but its role in prionoses remains unestablished. Using <italic>APOE</italic> targeted replacement (TR) mice, we investigated how <italic>APOE<...

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Literature Corpus work: 488cb88b-624b-58d3-9682-b65ffbaae5cc
DOI: 10.21203/rs.3.rs-7820890/v1

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