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Article

APOE Genotype Alters Immunoglobulin Subtypes in Knock-In Mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Zhou Ye, Zhao Wenjuan, Al-Muhtasib Nour, Rebeck G William

Abstract excerpt

Apolipoprotein E (APOE) alleles are strongly related to the risk of Alzheimer's disease (AD). APOE genotype also affects inflammatory processes in response to damage. We tested whether APOE genotype affected the levels of specific immunoglobulins in healthy, uninfected APOE knock-in mice. We measured specific immunoglobulins in brain, spleen, and plasma. Levels of total IgG in brain and spleen were highest in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25737044
DOI: 10.3233/JAD-142184
PMCID: PMC4963980

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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