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Article

APOE genotype differentially modulates prion pathology in a mouse model.

Acta neuropathologica communications - 21 Jan 2026

Lizińczyk Anita M, Pankiewicz Joanna E, Cullina William L, Franco Leor A, Sullivan Patrick M, Sadowski Martin J

Abstract excerpt

APOE polymorphism affects the risk of occurrence and the rate of progression in several neurodegenerative diseases including Alzheimer’s disease, primary tauopathies, α-synucleinopathy, and age-related macular degeneration, but its role in prionoses remains unestablished. Using APOE targeted replacement (TR) mice, we investigated how APOE genotype affects key neurodegenerative mechanisms involved in prion...

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Identifiers

PMID: 41566404
DOI: 10.1186/s40478-025-02207-5
PMCID: PMC12853611

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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