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Article

APOE genotype regulates pathology and disease progression in synucleinopathy.

Science translational medicine - 5 Feb 2020

Davis Albert A, Inman Casey E, Wargel Zachary M, Dube Umber, Freeberg Brittany M, Galluppi Alexander, Haines Jessica N, Dhavale Dhruva D, Miller Rebecca, Choudhury Fahim A, Sullivan Patrick M, Cruchaga Carlos, Perlmutter Joel S, Ulrich Jason D, Benitez Bruno A, Kotzbauer Paul T, Holtzman David M

Abstract excerpt

Apolipoprotein E (APOE) ε4 genotype is associated with increased risk of dementia in Parkinson's disease (PD), but the mechanism is not clear, because patients often have a mixture of α-synuclein (αSyn), amyloid-β (Aβ), and tau pathologies. APOE ε4 exacerbates brain Aβ pathology, as well as tau pathology, but it is not clear whether APOE genotype independently regulates αSyn pathology. In this study, we generated...

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Identifiers

PMID: 32024799
DOI: 10.1126/scitranslmed.aay3069
PMCID: PMC7289511

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