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Article

Impact of APOE genotype on prion-type propagation of tauopathy.

Acta neuropathologica communications - 19 Apr 2022

Williams Tristan, Ruiz Alejandra Jolie, Ruiz Angelica Maria, Vo Quan, Tsering Wangchen, Xu Guilian, McFarland Karen, Giasson Benoit I, Sullivan Patrick, Borchelt David R, Chakrabarty Paramita

Abstract excerpt

Apolipoprotein (APOE) is a major risk factor of Alzheimer's disease (AD), with the E2, E3 and E4 isoforms differentially regulating the burden of AD-associated neuropathologies, such as amyloid β and tau. In AD, pathological tau is thought to spread along neuroanatomic connections following a prion-like mechanism. To provide insights into whether APOE isoforms differentially regulate the prion properties of tau...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35440098
DOI: 10.1186/s40478-022-01359-y
PMCID: PMC9019935

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