Article
The prion diseases.
Journal of geriatric psychiatry and neurology - 1 Dec 2010
Brown Khalilah, Mastrianni James A
Abstract excerpt
The prion diseases are a family of rare neurodegenerative disorders that result from the accumulation of a misfolded isoform of the prion protein (PrP), a normal constituent of the neuronal membrane. Five subtypes constitute the known human prion diseases; kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS), fatal insomnia (FI), and variant CJD (vCJD). These subtypes are...
Topics
- Animals
- Brain
- Brain Stem
- Cerebellum
- Creutzfeldt-Jakob Syndrome
- Gerstmann-Straussler-Scheinker Disease
- Humans
- Insomnia, Fatal Familial
- Kuru
- Mutation
- Phenotype
- Prion Diseases
- Prion Proteins
- Prions
- Risk Factors
- Severity of Illness Index
- Thalamus