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Article

Absence of Apolipoprotein E is associated with exacerbation of prion pathology and promotes microglial neurodegenerative phenotype.

Acta neuropathologica communications - 26 Sept 2021

Pankiewicz Joanna E, Lizińczyk Anita M, Franco Leor A, Diaz Jenny R, Martá-Ariza Mitchell, Sadowski Martin J

Abstract excerpt

Prion diseases or prionoses are a group of rapidly progressing and invariably fatal neurodegenerative diseases. The pathogenesis of prionoses is associated with self-replication and connectomal spread of PrPSc, a disease specific conformer of the prion protein. Microglia undergo activation early in the course of prion pathogenesis and exert opposing roles in PrPSc mediated neurodegeneration. While clearance of...

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Identifiers

PMID: 34565486
DOI: 10.1186/s40478-021-01261-z
PMCID: PMC8474943

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