Chimeric antigen receptors that trigger phagocytosis

Abstract excerpt

Chimeric antigen receptors (CARs) are synthetic receptors that reprogram T cells to kill cancer. The success of CAR-T cell therapies highlights the promise of programmed immunity and suggests that applying CAR strategies to other immune cell lineages may be beneficial. Here, we engineered a family of Chimeric Antigen Receptors for Phagocytosis (CAR-Ps) that direct macrophages to engulf specific targets, including...

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• CAR-T cell therapy research
• Immune Cell Function and Interaction
• Phagocytosis and Immune Regulation